Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils

Author:

Hu Sheng-Quan12,Wang Rui3,Cui Wei12,Mak Shing-Hung12,Li Gang4,Hu Yuan-Jia5,Lee Ming-Yuen5,Pang Yuan-Ping6,Han Yi-Fan12

Affiliation:

1. Department of Applied Biology and Chemical Technology; The Hong Kong Polytechnic University; Hung Hom Hong Kong China

2. The Hong Kong Polytechnic University Shenzhen Research Institute; Shenzhen China

3. Department of Pharmaceutical Science; School of Pharmacy; Shanghai Key Laboratory of New Drug Design; East China University of Science and Technology; Shanghai China

4. National Engineering Laboratory for Modern Silk; College of Textile and Clothing Engineering; Soochow University; Suzhou China

5. State Key Laboratory of Quality Research in Chinese Medicine; Institute of Chinese Medical Sciences; University of Macau; Macau China

6. Computer-Aided Molecular Design Laboratory; Mayo Clinic; Rochester MN USA

Funder

Research Grants Council of Hong Kong

Hong Kong Polytechnic University

Fundo para o Desenvolvimento das Ciências e da Tecnologia

Universidade de Macau

Publisher

Wiley

Subject

Pharmacology (medical),Physiology (medical),Psychiatry and Mental health,Pharmacology

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