Affiliation:
1. Translational and Clinical Research Institute Newcastle University Newcastle Upon Tyne UK
2. Nuclear Medicine Department Newcastle Upon Tyne Hospitals NHS Foundation Trust Newcastle Upon Tyne UK
3. Centre for Research in Ageing and Cognitive Health University of Exeter Exeter UK
4. Department of Psychiatry, School of Clinical Medicine University of Cambridge Cambridge UK
Abstract
AbstractBackground and purposeMild cognitive impairment with Lewy bodies (MCI‐LB) is associated with a range of cognitive, motor, neuropsychiatric, sleep, autonomic, and visual symptoms. We investigated the cumulative frequency of symptoms in a longitudinal cohort of MCI‐LB compared with MCI due to Alzheimer disease (MCI‐AD) and analysed the ability of a previously described 10‐point symptom scale to differentiate MCI‐LB and MCI‐AD, in an independent cohort.MethodsParticipants with probable MCI‐LB (n = 70), MCI‐AD (n = 51), and controls (n = 34) had a detailed clinical assessment and annual follow‐up (mean duration = 1.7 years). The presence of a range of symptoms was ascertained using a modified version of the Lewy Body Disease Association Comprehensive LBD Symptom Checklist at baseline assessment and then annually.ResultsMCI‐LB participants experienced a greater mean number of symptoms (24.2, SD = 7.6) compared with MCI‐AD (11.3, SD = 7.4) and controls (4.2, SD = 3.1; p < 0.001 for all comparisons). A range of cognitive, parkinsonian, neuropsychiatric, sleep, and autonomic symptoms were significantly more common in MCI‐LB than MCI‐AD, although when present, the time of onset was similar between the two groups. A previously defined 10‐point symptom scale demonstrated very good discrimination between MCI‐LB and MCI‐AD (area under the receiver operating characteristic curve = 0.91, 95% confidence interval = 0.84–0.98), replicating our previous finding in a new cohort.ConclusionsMCI‐LB is associated with the frequent presence of a particular profile of symptoms compared to MCI‐AD. Clinicians should look for evidence of these symptoms in MCI and be aware of the potential for treatment. The presence of these symptoms may help to discriminate MCI‐LB from MCI‐AD.
Funder
Alzheimer’s Research UK
GE Healthcare
Medical Research Council
National Institute for Health Research Applied Research Collaboration South West Peninsula
NIHR Cambridge Biomedical Research Centre
NIHR Newcastle Biomedical Research Centre
Subject
Neurology (clinical),Neurology
Cited by
1 articles.
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