Cetuximab sensitivity of head and neck squamous cell carcinoma xenografts is associated with treatment-induced reduction in EGFR, pEGFR, and pSrc

Author:

Jedlinski Adam1,Garvin Stina2,Johansson Ann-Charlotte3,Edqvist Per-Henrik4,Ponten Fredrik4,Roberg Karin13

Affiliation:

1. Department of ENT - Head and Neck Surgery; County Council of Östergötland; Linköping Sweden

2. Department of Clinical Pathology and Department of Clinical and Experimental Medicine; Linköping University; Linköping Sweden

3. Division of Oto-Rhino-Laryngology and Head and Neck Surgery; Department of Clinical and Experimental Medicine; Linköping University; Linköping Sweden

4. Department of Immunology, Genetics and Pathology and Science for Life Laboratory; Rudbeck Laboratory; Uppsala University; Uppsala Sweden

Funder

Åke Wiberg Stiftelse

Cancerfonden

Länsstyrelsen Östergötland

The Research Funds of Linköping University Hospital

The Foundation of Magn

The Cancer Foundation of Östergötland

Publisher

Wiley

Subject

Periodontics,Cancer Research,Otorhinolaryngology,Oral Surgery,Pathology and Forensic Medicine

Reference23 articles.

1. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma;Ang;Cancer Res,2002

2. Epidermal growth factor-related peptides and their receptors in human malignancies;Salomon;Crit Rev Oncol Hematol,1995

3. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck;Bonner;N Engl J Med,2006

4. Effect of erlotinib on epidermal growth factor receptor and downstream signaling in oral cavity squamous cell carcinoma;Tsien;Head Neck,2013

5. EGFR status and EGFR ligand expression influence the treatment response of head and neck cancer cell lines;Jedlinski;J Oral Pathol Med,2013

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