Splenic lymphocyte subtypes in immune thrombocytopenia: increased presence of a subtype of B-regulatory cells

Author:

Aslam Rukhsana12,Segel George B.3,Burack Richard4,Spence Stephen A.4,Speck Edward R.1,Guo Li1,Semple John W.15672

Affiliation:

1. Keenan Research Centre for Biomedical Science; St. Michaels Hospital; Toronto ON Canada

2. Canadian Blood Services; Toronto ON Canada

3. Department of Medicine; University of Rochester School of Medicine; Rochester NY USA

4. Department of Pathology; University of Rochester School of Medicine; Rochester NY USA

5. Department of Pharmacology; University of Toronto; Toronto ON Canada

6. Department of Medicine; University of Toronto; Toronto ON Canada

7. Department of Laboratory Medicine and Pathobiology; University of Toronto; Toronto ON Canada

Funder

Canadian Blood Services R&D Research Grant

National Center for Advancing Translational Sciences of the National Institutes of Health

Publisher

Wiley

Subject

Hematology

Reference6 articles.

1. Thymic retention of CD4 + CD25 + Foxp3 +  T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia;Aslam;Blood,2012

2. Immunologic effects of rituximab on human spleen in immune thrombocytopenia;Audia;Blood,2011

3. Changes in peripheral CD19 + Foxp3 +  and CD19 + TGFβ+ regulatory B cell populations in rheumatoid arthritis patients with interstitial lung disease;Guo;Journal of Thoracic Disease,2015

4. Defective regulatory B-cell compartment in patient with immune thrombocytopenia;Li;Blood,2012

5. Cellular immune disfunction in immune thrombocytopenia (ITP);McKenzie;British Journal Haematology,2013

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