The anti-cancer agent SU4312 unexpectedly protects against MPP+-induced neurotoxicity via selective and direct inhibition of neuronal NOS

Author:

Cui Wei1,Zhang Zaijun,Li Wenming,Hu Shengquan1,Mak Shinghung1,Zhang Huan1,Han Renwen1,Yuan Shuai2,Li Sai3,Sa Fei2,Xu Daping2,Lin Zhixiu4,Zuo Zhong5,Rong Jianhui6,Ma Edmond Dik-Lung7,Choi Tony Chunglit1,Lee Simon MY2,Han Yifan1

Affiliation:

1. Department of Applied Biology and Chemical Technology; Institute of Modern Medicine; The Hong Kong Polytechnic University; Hong Kong; China

2. State Key Laboratory of Quality Research in Chinese Medicine; Institute of Chinese Medical Sciences; University of Macau; Macau; China

3. Institute of New Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic; Constituents of Traditional Chinese Medicine & New Drug Research; College of Pharmacy; Jinan University; Guang Zhou; China

4. School of Chinese Medicine; The Chinese University of Hong Kong; Hong Kong; China

5. School of Pharmacy; The Chinese University of Hong Kong; Hong Kong; China

6. School of Chinese Medicine; The University of Hong Kong; Hong Kong; China

7. Department of Chemistry; Hong Kong Baptist University; Hong Kong; China

Publisher

Wiley

Subject

Pharmacology

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