Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K+channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells

Author:

Jehle J1,Ficker E2,Wan X2,Deschenes I2,Kisselbach J1,Wiedmann F1,Staudacher I1,Schmidt C1,Schweizer PA1,Becker R1,Katus HA1,Thomas D1

Affiliation:

1. Department of Cardiology; Medical University Hospital; Heidelberg; Heidelberg; Germany

2. Rammelkamp Center, MetroHealth Campus; Case Western Reserve University; Cleveland; OH; USA

Publisher

Wiley

Subject

Pharmacology

Reference59 articles.

1. Guide to Receptors and Channels (GRAC), 5th edition;Alexander;Br J Pharmacol,2011

2. Herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?;Bianchi;Cancer Res,1998

3. In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes;Caspi;Stem Cells Dev,2009

4. HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium;Cherubini;Br J Cancer,2000

5. HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte;Claycomb;Proc Natl Acad Sci U S A,1998

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