Affiliation:
1. Michael G. DeGroote School of Medicine McMaster University Hamilton Canada
2. Temerty Faculty of Medicine University of Toronto Toronto Canada
3. Division of Pediatric Dermatology The Hospital for Sick Children, University of Toronto Toronto Canada
Abstract
AbstractOur study aims to synthesize existing evidence of dupilumab for alopecia areata (AA) in pediatric patients with atopic dermatitis (AD). We searched MEDLINE and Embase on March 1, 2024, using keywords related to AD, AA, dupilumab, and pediatric patient populations per PRISMA‐ScR guidelines. A mean SALT score reduction of 42.6 following dupilumab treatment (p < .01) over an average of 3.21 months, and a mean reduction of Investigator Global Assessment (IGA) levels of 2.14 units (p < .01) demonstrates the efficacy of dupilumab in pediatric AA when there is concurrent AD. Our findings in combination with dupilumab's favorable safety profile in pediatric AD makes it an appealing option for AA treatment, however, a greater understanding of the underlying mechanisms, optimal pediatric patient selection criteria, long‐term efficacy, and safety profile of dupilumab in this context is warranted.