Antiphospholipid syndrome in cardiovascular disease and cancer

Author:

Pessach Ilias1ORCID,Kyriakou Elias2,Kalampokas Emmanouil3ORCID,Kalampokas Theodoros4ORCID,Bitsani Aikaterini5ORCID,Kotsianidis Ioannis6ORCID

Affiliation:

1. Hematology Department Athens Medical Center Athens Greece

2. Laboratory of Hematology and Blood Bank Unit, National and Kapodistrian University of Athens, Medical School "Attikon" University General Hospital Athens Greece

3. Unit of Gynecologic Oncology, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School National and Kapodistrian University of Athens Athens Greece

4. Unit of Obstetrics and Gynecology, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School National and Kapodistrian University of Athens Athens Greece

5. First Department of Propedeutic Internal Medicine, Laiko General Hospital, Medical School National and Kapodistrian University of Athens Athens Greece

6. Department of Hematology, University Hospital of Alexandroupolis Democritus University of Thrace Alexandroupolis Greece

Abstract

AbstractAntiphospholipid syndrome is an autoimmune disorder which is characterized by the presence of heterogeneous antiphospholipid antibodies. There is an evidence on antiphospholipid (aPL) antibodies related to thromboembolic events in cancer patients. In fact, the thrombotic complications in patients with malignancy occur at a rather high frequency, compared to other risk factors. In parallel with standard therapies available, there is need of case‐by‐case monitoring of each patient and the introduction of new therapies and need for more clinical trials which will address many questions for the optimal management of patients. This paper presents a basic review of the literature on the aPL antibodies associated with cardiovascular disease and cancer, as well as its complications, which are reported so far in the bibliography.

Publisher

Wiley

Subject

Hematology,General Medicine

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