Integrated phenotype–genotype approach in diagnosis and classification of common central nervous system tumours

Author:

Merve Ashirwad123ORCID,Millner Thomas O1,Marino Silvia1

Affiliation:

1. Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of LondonLondon UK

2. Division of Neuropathology UCL Institute of Neurology National Hospital for Neurology and NeurosurgeryLondon UK

3. Department of Histopathology Camelia Botnar Laboratory Great Ormond Street Hospital for Children NHS Foundation Trust London UK

Funder

National Institute for Health Research

Medical Research Council

Brain Tumour Charity

Publisher

Wiley

Subject

General Medicine,Histology,Pathology and Forensic Medicine

Reference40 articles.

1. UK CR.Brain other CNS and intracranial tumours incidence statistics: Cancer Research UK;2017[updated January 2018. Data obtained from the Office for National Statistics (July 2017); ISD Scotland (August); Welsh Cancer Intelligence and Surveillance Unit Health Intelligence Division Public Health Wales (October); the Northern Ireland Cancer Registry (July). Data are for UK 5 ICD‐10 C70‐C72 C75.1‐C75.3 D32‐D33 D35.2‐D35.4 D42‐D43 D44.3‐D44.5.]. Available at:http://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/brain-other-cns-and-intracranial-tumours/incidence#heading-One. Date accessed 14 January 2019.

2. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

3. The 2007 WHO Classification of Tumours of the Central Nervous System

4. ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

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