Estimation of drug receptor occupancy when non-displaceable binding differs between brain regions - extending the simplified reference tissue model

Author:

Kågedal Matts12ORCID,Varnäs Katarina3,Hooker Andrew C.2,Karlsson Mats O.2

Affiliation:

1. AstraZeneca R&D; SE-151 85 Södertälje Sweden

2. Department of Pharmaceutical Biosciences; Uppsala University; Uppsala Sweden

3. Karolinska Institutet; Department of Clinical Neuroscience; Center for Psychiatric Research and Education; Karolinska Hospital; S-171 76 Stockholm Sweden

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference18 articles.

1. Simplified reference tissue model for PET receptor studies;Lammertsma;Neuroimage,1996

2. Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-(11)C]WAY-100635-considerations on the validity of cerebellum as a reference region;Hirvonen;J Cereb Blood Flow Metab,2007

3. Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography;Parsey;J Cereb Blood Flow Metab,2005

4. Central benzodiazepine receptors in human brain: estimation of regional Bmax and KD values with positron emission tomography;Abadie;Eur J Pharmacol,1992

5. Quantification and fatty acid and fatty aldehyde composition of ethanolamine, choline, and serine glycerophosphatides in human cerebral grey and white matter;O'Brien;J Lipid Res,1964

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