Switching from rivaroxaban to warfarin: an open label pharmacodynamic study in healthy subjects

Author:

Moore Kenneth Todd1,Byra William2,Vaidyanathan Seema3,Natarajan Jaya2,Ariyawansa Jay2,Salih Hiba4,Turner Kenneth C.1

Affiliation:

1. Janssen Research & Development, LLC Titusville NJ

2. Janssen Research & Development, LLC Raritan NJ

3. Janssen Research & Development, LLC Springhouse PA USA

4. Clinical Pharmacology Unit Janssen Pharmaceutica NV Antwerp Belgium

Funder

Janssen Research & Development, LLC

Bayer HealthCare Pharmaceuticals

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference15 articles.

1. Bayer Pharma AG.Xarelto® (rivaroxaban) Summary of Product Characteristics.2014. Available athttp://www.ema.europa.eu/docs/en_GB/document_library/EPAR_‐_Product_Information/human/000944/WC500057108.pdf(last accessed 23 December 2014).

2. Janssen Pharmaceuticals Inc.Xarelto® (rivaroxaban) Prescribing Information.2014. Available athttp://www.accessdata.fda.gov/drugsatfda_docs/label/2013/202439s008lbl.pdf(last accessed 7 January 2015).

3. Bristol‐Myers Squibb.Coumadin (warfarin sodium) Prescribing Information.2011. Available athttp://packageinserts.bms.com/pi/pi_coumadin.pdf(last accessed 6 August 2014).

4. Pharmacodynamics and pharmacokinetics during the transition from warfarin to rivaroxaban: a randomized study in healthy subjects

5. Determination of rivaroxaban – a novel, oral, direct Factor Xa inhibitor – in human plasma by high-performance liquid chromatography–tandem mass spectrometry

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