Affiliation:
1. Division of Hematology & Medical Oncology, Department of Internal Medicine Soonchunhyang University Seoul Hospital Seoul South Korea
2. Division of Cardiology, Department of Internal Medicine Soonchunhyang University Seoul Hospital Seoul South Korea
3. Division of Hematology & Medical Oncology, Department of Internal Medicine Soonchunhyang University Bucheon Hospital Bucheon South Korea
Abstract
AbstractIntroductionThe role of inflammation in the pathophysiology of polycythemia vera (PV) is important. The presence of JAK2 mutations is important in the diagnosis of PV, and serum levels of erythropoietin (EPO) also play a supporting role. However, serum EPO levels show some limitations. The neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) are a readily available marker of inflammation. Thus, we examined whether NLR & PLR might diagnose PV in erythrocytosis patients. We compared NLR & PLR and EPO diagnostic values.MethodsWe retrospectively reviewed clinical and laboratory data from two referral hospitals. Two hundred and eighty‐five patients with erythrocytosis who underwent a test for the JAK2 mutation were included. It wac classified as the PV group and the secondary polycythemia (SP) group.ResultsThe median NLR & PLR in the PV group (n = 70) was significantly higher than that in the SP group (n = 170) (NLR: 6.04 vs. 1.77, PLR: 283.18 vs. 101.56, respectively, p < 0.001). In the receiver operating characteristic analysis, the area under the curve of NLR & PLR was significantly higher than that of serum EPO (NLR vs EPO: 0.921 vs. 0.827, p = 0.003; PLR vs EPO: 0.917 vs 0.827, p = 0.003).ConclusionIn conclusion, NLR & PLR were higher in PV than in SP and showed better diagnostic value than serum EPO level, highlighting their potential as minor diagnostic criteria in patients with PV.
Subject
Biochemistry (medical),Clinical Biochemistry,Hematology,General Medicine
Reference19 articles.
1. Diagnostic value of serum erythropoietin level in patients with absolute erythrocytosis;Mossuz P;Haematologica,2004
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