1. Department of Dermatology, Faculty of Medicine; University of the Ryukyus; Okinawa Japan
2. Department of Bioscience and Biotechnology, College of Agriculture; University of the Ryukyus; Okinawa Japan
3. Laboratory of Physiology & Pharmacology, School of Health Sciences, Faculty of Medicine; University of the Ryukyus; Okinawa Japan
4. Department of Analytical and Bioinorganic Chemistry, School of Pharmacy; Kyoto Pharmaceutical University; Kyoto Japan