Myoclonus in patients with COVID‐19: Findings of autoantibodies against brain structures in cerebrospinal fluid-Reference-Cited by-同舟云学术

Myoclonus in patients with COVID‐19: Findings of autoantibodies against brain structures in cerebrospinal fluid

Published:2023-07-13 Issue:10 Volume:30 Page:3142-3148
ISSN:1351-5101
Container-title:European Journal of Neurology
language:en
Short-container-title:Euro J of Neurology

Author:

Lindqvist Isa¹²,Cunningham Janet L.¹²,Mulder Jan²,Feresiadou Amalia³,Rostami Elham²⁴,Virhammar Johan³^ORCID,Kumlien Eva³^ORCID

Affiliation:

1. Department of Medical Sciences, Psychiatry Uppsala University Uppsala Sweden

2. Department of Neuroscience Karolinska Institute Stockholm Sweden

3. Department of Medical Sciences, Neurology Uppsala University Uppsala Sweden

4. Department of Medical Sciences, Neurosurgery Uppsala University Uppsala Sweden

Abstract

AbstractBackground and purposeCOVID‐19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID‐19 infection, with no previous neurological disease, are decsribed.MetodsAnalysis of cerebrospinal fluid from the cases using indirect immunohistochemistry.ResultsAntibodies against rodent brain tissue, and similarities in staining patterns were observed, indicating the presence of antineuronal immunoglobulin G autoantibodies targeting astrocytes in the hippocampus.ConclusionOur results demontrate cerebrospinal fluid antineuronal antibodies indicating an an autoimmune involvment in the pathogenesis in COVID‐19 associated myoclonus.

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ene.15958

Reference28 articles.

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5. Autoimmune Encephalitis Presenting With Malignant Catatonia in a 40-Year-Old Male Patient With COVID-19

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