Affiliation:
1. Department of Pathology Hiroshima City Hiroshima Citizens Hospital Hiroshima Japan
2. Department of Pathology Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital Tokyo Japan
3. Department of Pathology Itabashi Central Clinical Laboratory Tokyo Japan
4. Department of Diagnostic Pathology Tokyo Medical University Hospital Tokyo Japan
5. Department of Diagnostic Pathology Shizuoka Cancer Center Hospital Sunto Japan
6. Department of Diagnostic Pathology Chutoen General Medical Center Kakegawa Japan
Abstract
AbstractBackgroundTranscriptional repressor GATA binding 1 (TRPS1) is a transcription factor recently shown to play a role in the development of breast and liver cancer. Here, we evaluate TRPS1 immunoexpression in normal skin tissues and various cutaneous tumors.MethodsTRPS1 immunohistochemistry was performed in 109 cases of primary cutaneous tumors and 19 cases of metastatic carcinomas. TRPS1 expression was also evaluated in the normal skin tissues.ResultsThe normal epidermis was TRPS1−. In contrast, the eccrine apparatus, epithelial compartment of the hair follicles, hair papilla, sebaceous glands, and anogenital mammary‐like glands were TRPS1+. In primary cutaneous tumors, TRPS1 positivity varied in poroma (2/3), nodular hidradenoma (4/5), spiradenoma (4/4), cutaneous mixed tumor (5/5), trichilemmal cyst (7/8), proliferating trichilemmal tumor (1/3), pilomatricoma (9/9), sebaceoma (2/5), extramammary Paget disease (13/13), sebaceous carcinoma (2/2), actinic keratosis (3/10), Bowen disease (7/12), and squamous cell carcinoma (1/5) cases. All cases of seborrheic keratosis, basal cell carcinoma, Merkel cell carcinoma, and malignant melanoma were TRPS1−. All metastatic breast carcinoma cases (8/8) were highly positive for TRPS1, while all but one of the other metastatic tumor cases were TRPS1−.ConclusionsTRPS1 immunoexpression was observed in several skin appendages and cutaneous tumors.
Subject
Dermatology,Histology,Pathology and Forensic Medicine