Affiliation:
1. School of Medicine Federal University of Goiás Goiânia Brazil
2. Department of Pediatric Gastroenterology State Hospital for Children and Adolescents Goiânia Brazil
3. Department of Otorhinolaryngology Federal University of Goiás Goiânia Brazil
4. Department of Pediatrics Federal University of Goiás Goiânia Brazil
Abstract
AbstractAimThis study is a systematic review and meta‐analysis of randomised controlled trials that employed probiotics and symbiotics for treating infantile colic.MethodsWe performed electronic systematic literature searches in Embase, PubMed and Web of Science, to identify articles published between 1950 and April 2023. Only RCT involving infants with infantile colic under 3 months were included. The treatment plan comprised 15 probiotics, which included Lactobacillus reuteri DSM 17938 and Bifidobacterium animalis lactis BB‐12. The probiotics were administered alone or in combination with a prebiotic, vs. no intervention or a placebo.ResultsProbiotics resulted in an average reduction of 51 min of crying per day (p = 0.001). Further analysis of subgroups showed that the reduction was −39.30 min for vaginal delivery (p = 0.003), −64.66 min for Lactobacillus reuteri DSM 17938 (p = 0.03), −40.45 min for other strains (p < 0.00001), −74.28 min for exclusively breastfed infants (p = 0.0003) and −48.04 min for mixed feeding (p < 0.00001).ConclusionAll probiotic strains seem effective in treating infantile colic. Exclusively breastfed infants have demonstrated more significant reduction in crying time. However, the available evidence on the effectiveness of probiotics in formula‐fed and caesarean‐born infants is limited.
Subject
General Medicine,Pediatrics, Perinatology and Child Health
Cited by
1 articles.
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1. Issue highlights;Acta Paediatrica;2024-01-11