Studies in children with obesity in two European treatment centres show a high prevalence of impaired glucose metabolism in the Swedish cohort

Abstract

AbstractAimTo investigate the prevalence and possible risk factors for the development of impaired glucose metabolism in children and adolescents with obesity.MethodsThis was a cross‐sectional retrospective cohort study, including 634 patients with obesity and 98 normal weight controls aged 4–18 years from the Beta‐cell function in Juvenile Diabetes and Obesity (Beta‐JUDO) cohort, a dual‐centre study at Uppsala University Hospital (Sweden) and Paracelsus Medical University Hospital (Salzburg, Austria) conducted between 2012 and 2021. A longitudinal subgroup analysis, including 188 of these subjects was performed. Impaired glucose metabolism was diagnosed by oral glucose tolerance tests according to American Diabetes Association criteria.ResultsThe prevalence of impaired glucose metabolism was 72% in Uppsala patients, 24% in Salzburg patients, 30% in Uppsala controls and 13% in Salzburg controls. The prevalence was lower at the follow‐up visits compared with baseline both in Uppsala and Salzburg patients. A family history of type 2 diabetes showed the strongest association with impaired glucose metabolism at the follow‐up visits besides belonging to the Uppsala cohort.ConclusionThe prevalence of impaired glucose metabolism was extraordinarily high in Swedish children and adolescents with obesity, but decreased during the follow‐up period.