α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice

Author:

Brusco Indiara1,Camponogara Camila1,Carvalho Fabiano Barbosa1,Schetinger Maria Rosa Chitolina1,Oliveira Mauro Schneider2,Trevisan Gabriela2,Ferreira Juliano3,Oliveira Sara Marchesan14ORCID

Affiliation:

1. Graduate Program in Biological Sciences, Biochemistry Toxicology; Federal University of Santa Maria; Santa Maria RS Brazil

2. Graduate Program in Pharmacology, Department of Physiology and Pharmacology; Federal University of Santa Maria; Santa Maria RS Brazil

3. Graduate Program in Pharmacology, Department of Pharmacology; Federal University of Santa Catarina; Florianopolis SC Brazil

4. Department of Biochemistry and Molecular Biology; Federal University of Santa Maria; Santa Maria RS Brazil

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul - FAPERGS

Publisher

Wiley

Subject

Pharmacology

Reference76 articles.

1. The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels;Alexander;Br J Pharmacol,2015a

2. The Concise Guide to PHARMACOLOGY 2015/16: Enzymes;Alexander;Br J Pharmacol,2015b

3. Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation;Boller;J Ethnopharmacol,2010

4. Anti-inflammatory action of hydroalcoholic extract, dichloromethane fraction and steroid α-spinasterol from Polygala sabulosa in LPS-induced peritonitis in mice;Borges;J Ethnopharmacol,2014

5. Potentiation of paclitaxel-induced pain syndrome in mice by angiotensin i converting enzyme inhibition and involvement of kinins;Brusco;Molecul Neurobiol,2016

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