Intranasal oxytocin does not change partner preference in female titi monkeys (Plecturocebus cupreus), but intranasal vasopressin decreases it

Author:

Zablocki‐Thomas Pauline1ORCID,Lau Allison12,Witczak Lynea13,Dufek Madison1,Wright Amber1,Savidge Logan13,Paulus John14,Baxter Alexander13ORCID,Karaskiewicz Chloe13,Seelke Adele M. H.5,Freeman Sara M.16ORCID,Ferrer Emilio5,Bales Karen L.135

Affiliation:

1. California National Primate Research Center Davis California USA

2. Graduate Group in Animal Behavior, University of California Davis California USA

3. Department of Psychology University of California Davis California USA

4. Graduate Group in Neuroscience, University of California Davis California USA

5. Department of Neurobiology, Physiology, and Behavior University of California Davis California USA

6. Department of Biology Utah State University Logan Utah USA

Abstract

AbstractStrong social bonds are critical to human health; however, the mechanisms by which social bonds are formed and maintained are still being elucidated. The neurohormones oxytocin (OT) and vasopressin (AVP) are considered likely candidates. Primate females, both human and nonhuman, remain understudied populations. Here, we conducted a pharmacological study coupled with a behavioral partner preference test (PPT) to better understand the mechanistic basis of attachment in adult female titi monkeys (Plecturocebus cupreus). This pair‐bonding species shares a conserved form of oxytocin with humans and is an excellent model organism to study the neural basis of social bonding. We performed intranasal administration of three doses of oxytocin (IN‐OT), two doses of vasopressin (IN‐AVP), one dose of an oxytocin antagonist (IN‐OTA) and one dose of a saline treatment. We found that compared to the saline control, the IN‐AVP treatment (lower dose, 40 IU/kg) decreased the time spent in proximity to the partner and increased lip‐smacking toward the stranger. We found no effects of IN‐OT or IN‐OTA manipulation on partner preference. In contrast, low‐dose IN‐AVP weakened the partner preference in female titi monkeys.

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Endocrine and Autonomic Systems,Endocrinology,Endocrinology, Diabetes and Metabolism

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