Pedunculopontine tegmentum cholinergic loss leads to a progressive decline in motor abilities and neuropathological changes resembling progressive supranuclear palsy
Author:
Affiliation:
1. Department of Pharmacology and Toxicology; Jacobs School of Medicine and Biomedical Sciences; University at Buffalo; Buffalo New York USA
Funder
CurePSP
Publisher
Wiley
Subject
General Neuroscience
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/ejn.14212/fullpdf
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5. Fusion of diphtheria toxin and urotensin II produces a neurotoxin selective for cholinergic neurons in the rat mesopontine tegmentum;Clark;Journal of Neurochemistry,2007
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1. Inhibiting cholinergic signalling in the cerebellar interpositus nucleus impairs motor behaviour;European Journal of Neuroscience;2023-07-16
2. Human wildtype tau expression in cholinergic pedunculopontine tegmental neurons is sufficient to produce PSP‐like behavioural deficits and neuropathology;European Journal of Neuroscience;2021-11
3. Alteration of Mesopontine Cholinergic Function by the Lack of KCNQ4 Subunit;Frontiers in Cellular Neuroscience;2021-07-26
4. Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial;The Lancet Neurology;2021-03
5. Effects of pedunculopontine nucleus cholinergic lesion on gait and dyskinesia in hemiparkinsonian rats;European Journal of Neuroscience;2021-01-24
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