Low B‐cell content is associated with a <scp>CD73</scp>‐low tumour microenvironment and unfavourable prognosis in classic Hodgkin lymphoma-Reference-Cited by-同舟云学术

Low B‐cell content is associated with a CD73‐low tumour microenvironment and unfavourable prognosis in classic Hodgkin lymphoma

Published:2023-03-15 Issue:6 Volume:201 Page:1097-1102
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Grund Johanna¹,Iben Katharina¹,Reinke Sarah¹,Bühnen Ina²³,Plütschow Annette²³,Müller‐Meinhard Berit¹,Garcia Marquez Maria A.⁴⁵,Schlößer Hans A.⁴⁵,von Tresckow Bastian²³⁶,Kellermeier Fabian⁷,Borchmann Peter²³,Engert Andreas²³,Bröckelmann Paul J.²³⁸⁹,Klapper Wolfram¹^ORCID

Affiliation:

1. Hematopathology Section and Lymph Node Registry, Department of Pathology University Hospital Schleswig‐Holstein Kiel Germany

2. Department I of Internal Medicine, Centre for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO ABCD), Faculty of Medicine and University Hospital of Cologne University of Cologne Cologne Germany

3. German Hodgkin Study Group (GHSG) Cologne Germany

4. Center of Molecular Medicine, Cologne Translational Immunology University of Cologne Cologne Germany

5. Department of General, Visceral, Cancer and Transplantation Surgery; Faculty of Medicine and University Hospital of Cologne University of Cologne Cologne Germany

6. Department of Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen University of Duisburg‐Essen Essen Germany

7. Institute of Functional Genomics University of Regensburg Regensburg Germany

8. Mildred Scheel School of Oncology Aachen Bonn Cologne Düsseldorf (MSSO ABCD) Cologne Germany

9. Max Planck Institute for Biology of Ageing Cologne Germany

Abstract

SummaryB‐cell content in the tumour microenvironment (TME) of classic Hodgkin lymphoma (HL) is known to be associated with prognosis. Here we demonstrate that whole slide image analysis using routinely available slides predicts outcomes in patients treated with ABVD in a prospective trial with a high B‐cell content being associated with a favourable prognosis. B cells in the TME did not correlate with B cells in peripheral blood. In the TME maturation, stages of B cells (naive and memory) were consistent. However, we detected down‐regulation of CD73 in HL with low B cells suggestive of an antibody‐independent function of B cells in the TME of HL.

Publisher

Wiley

Subject

Hematology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.18762

Reference15 articles.

1. The microenvironmental niche in classic Hodgkin lymphoma is enriched for CTLA-4- positive T-cells that are PD-1-negative

2. B cells in classical Hodgkin lymphoma are important actors rather than bystanders in the local immune reaction

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