Determination of Octanol-water Partition Coefficients by an HPLC Method for Anticonvulsant Structure-activity Studies-Reference-Cited by-同舟云学术

Determination of Octanol-water Partition Coefficients by an HPLC Method for Anticonvulsant Structure-activity Studies

Published:1995-04 Issue:4 Volume:47 Page:345-347
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Henczi Maria¹,Nagy Jeno¹,Weaver Donald F²¹

Affiliation:

1. Department of Chemistry, Queen's University, Kingston, K7L 3N6, Canada

2. Department of Medicine, Queen's University, Kingston, K7L 3N6, Canada

Abstract

Abstract Octanol-water partition coefficients have been measured and calculated for eight clinically relevant anticonvulsants. For some compounds, these are the first experimentally available log P values. For the remainder of the molecules, new values have been suggested. The utility of the micro shake-flask experimental method and the ALOGP calculational method in determining anticonvulsant log P values has been demonstrated.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/47/4/345/36998634/j.2042-7158.1995.tb05807.x.pdf

Reference15 articles.

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3. Transplacental transfer and biotransformation studies of valproic acid and its glucuronides in the perfused human placenta;Fowler;J. Pharmacol. Exp. Ther.,1989

4. Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships III;Ghose;J. Comp. Chem.,1988

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