Spectroscopic Analysis of the Binding of Amylobarbitone, Secbutobarbitone, Pentobarbitone, Phenobarbitone and Quinalbarbitone to Human Serum Albumin-Reference-Cited by-同舟云学术

Spectroscopic Analysis of the Binding of Amylobarbitone, Secbutobarbitone, Pentobarbitone, Phenobarbitone and Quinalbarbitone to Human Serum Albumin

Published:1995-05 Issue:5 Volume:47 Page:436-441
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

González-Jimènez J¹,Moreno F¹,Blanco F Garcìa¹

Affiliation:

1. Instituto Pluridisciplinar, Departamento de Quimica Fisica Farmaceutica, Facultad de Farmacia, 28040 Madrid, Spain

Abstract

Abstract The binding of five barbiturates: amylobarbitone, secbutobarbitone, pentobarbitone, phenobarbitone and quinalbarbitone to human serum albumin (HSA) was studied by difference spectroscopy and spectro-fluorimetric titrations. There were no changes in the HSA spectral properties. Our result suggest that there are two classes of binding sites on HSA for these barbiturates. A detailed investigation of the effect of their binding to HSA by deconvoluted spectra, suggests that the interaction of barbiturate-HSA takes place principally on the subdomain IIIA of HSA.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/47/5/436/36998625/j.2042-7158.1995.tb05825.x.pdf

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