Synthesis and Antiplatelet Effects of ω-Aminoalkoxylxanthones-Reference-Cited by-同舟云学术

Synthesis and Antiplatelet Effects of ω-Aminoalkoxylxanthones

Published:1995-07 Issue:7 Volume:47 Page:588-594
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Lin Chun-Nan¹,Liou Shorong-Shii¹,Lai Shih-Chen¹,Lin Hsien-Cheng²,Ko Feng-Nien³,Liu Hong-Wen⁴,Teng Che-Ming³

Affiliation:

1. School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan 807, ROC

2. School of Technology for Medical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan 807, ROC

3. Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, 100, ROC

4. Department of Internal Medicine, Kaohsiung Medical College, Kaohsiung, Taiwan 807, ROC

Abstract

Abstract A series of ω-aminoalkoxylxanthones were synthesized and tested in-vitro for their ability to inhibit aggregation of rabbit washed platelets and human platelet-rich plasma (PRP) induced by various inducers. Nine of these compounds showed more potent antiplatelet effects than natural norathyriol tetraacetate on collagen-induced aggregation. The various ω-aminoalkoxyl side chains of the synthesized compounds modified the antiplatelet effects. All the compounds tested in human PRP showed significant inhibition of secondary aggregation induced by adrenaline, suggesting that the antiplatelet effects of these compounds is mainly due to an inhibitory effect on thromboxane formation. These compounds at high concentration also cause vasorelaxing action in rat thoracic aorta.

Funder

National Sciences Council, ROC, Public Health, Executive Yuan, ROC

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/47/7/588/36998708/j.2042-7158.1995.tb06720.x.pdf

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