Affiliation:
1. Department of Physiology, University of Queensland, St Lucia, Q'ld. 4067, Australia
Abstract
Abstract
Dye leakage in rats produced by intracutaneous injections of irritants was quantitated using an azovan blue technique. Concentration-response lines were obtained for irritants alone and in presence of constant concentrations of other irritants. 5-Hydroxytryptamine (5-HT) (10−7m) potentiated histamine, bradykinin and prostaglandin E1 (PGE1), but inhibited adenosine-5′-triphosphate (ATP). Histamine (10−5m) potentiated bradykinin, PGE1 and ATP. Bradykinin (10−6m) potentiated PGE1 only, but PGE1 (10−6m) potentiated bradykinin, 5-HT and histamine. ATP (10−4m) potentiated 5-HT, histamine and PGE1. Release of ATP during stimulation of sensory nerves might explain enhanced neurogenic oedema observed in skin surrounding an area pretreated with compound 48/80.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
26 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献