A model independent method for estimating the in vivo release rate constant of a drug from its oral formulations-Reference-Cited by-同舟云学术

A model independent method for estimating the in vivo release rate constant of a drug from its oral formulations

Published:1976-06 Issue:6 Volume:28 Page:505-507
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Vaughan D P¹

Affiliation:

1. School of Pharmacy and Biology, Sunderland Polytechnic, Chester Road, Sunderland SR1 3SD, U.K.

Abstract

Abstract A simple equation by which the first-order release rate constant of a drug from its oral formulation can be calculated is derived. The derivation is independent of any hypothetical concepts of drug distribution or elimination.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/28/6/505/37613641/j.2042-7158.1976.tb02775.x.pdf

Reference6 articles.

1. New Method for Calculating the Intrinsic Absorption Rate of Drugs

2. A general method of determining the first order input rate constant of a drug that is directly absorbed into the central compartment

3. Derivation of general equations for linear mammillary models when the drug is administered by different routes

4. Application of the Wagner-Nelson absorption method to the two-compartment open model

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