Enhancement of ethanol-induced withdrawal convulsions by blockade of 5-hydroxytryptamine receptors-Reference-Cited by-同舟云学术

Enhancement of ethanol-induced withdrawal convulsions by blockade of 5-hydroxytryptamine receptors

Published:1976-11 Issue:11 Volume:28 Page:832-835
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Blum Kenneth¹,Wallace Jack E¹,Schwertner Harvey A¹,Eubanks J D¹

Affiliation:

1. University of Texas Health Science Centre, Departments of Pharmacology and Pathology, San Antonio, Texas 78284, U.S.A.

Abstract

Abstract Male Swiss-Webster mice were made physically dependent on ethanol using the ethanol vapour inhalation technique. Animals pretreated with methysergide, a known 5-hydroxytryptamine receptor blocking agent, had significantly greater alcohol-induced withdrawal convulsions than saline pretreated controls. These findings suggest that the reduction of 5-HT at receptor sites may result in the augmentation of the withdrawal convulsions.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/28/11/832/37613913/j.2042-7158.1976.tb04066.x.pdf

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