Re-evaluation of the L-dopa loading effect on dopamine metabolism in rat striatum

Author:

El Gemayel G1,Trouvin J H1,Prioux-Guyonneau M1,Jacquot C1,Cohen Y1

Affiliation:

1. Laboratoire de Pharmacologie UA CNRS 594, Faculte de Pharmacie, Chatenay-Malabry, F-92290 France

Abstract

Abstract Investigation by HPLC with electrochemical detection of dopamine (DA) metabolism in rat striatum after L-dopa + benserazide treatment allowed quantification of the time course evolution of DA, 3,4-dihydroxyphenylacetic acid and homovanillic acid levels. Furthermore, four peaks which did not appear in controls, were detected in treated striatum. One was identified as 3-methoxytyrosine, the level of which was still high 9 h after treatment. 3-Methoxytyrosine, has been detected previously in plasma of parkinsonian patients treated with L-dopa, and the disturbance in DA metabolism could explain some of the side-effects induced by that treatment.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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