The influence of oxygen tension on theophylline clearance in the rat isolated perfused liver-Reference-Cited by-同舟云学术

The influence of oxygen tension on theophylline clearance in the rat isolated perfused liver

Published:1986-03 Issue:3 Volume:38 Page:236-238
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Miller Raymond¹,Oliver Isabel F²

Affiliation:

1. Department of Pharmacology, University of Durban-Westville, Private Bag X54001, Durban 4000

2. Department of Pharmacology, Potchefstroom University for CHE, Potchefstroom 2520, South Africa

Abstract

Abstract The effect of changes in the rate of perfusion and oxygen tension (Po2) on theophylline clearance was determined in the rat isolated perfused liver. Changes in rate of perfusion had no effect on the extraction ratio of theophylline while a decrease in the Po2 significantly increased the half life of theophylline. These results suggest that changes in Po2 whether due to disease states or oxygen administration may necessitate theophylline dosage adjustment.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/38/3/236/37553557/j.2042-7158.1986.tb04555.x.pdf

Reference15 articles.

1. Pharmacokinetics in Patients with Cardiac Failure

2. Comparison of the Induction Course, Biophysical Chemical Interactions and Photochemical Action Spectra of Phenobarbital and 3-Methylcholanthrene Induced Hepatic Microsomal P-450

3. Factors affecting theophylline clearances: Age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol

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