Concentration and pH dependency of α-methyldopa absorption in rat intestine

Author:

Amidon G L1,Merfeld A E2,Dressman J B2

Affiliation:

1. College of Pharmacy, The University of Michigan, Ann Arbor, Michigan 48109-1065, USA

2. INTERx, Merck Sharp & Dohme Research Laboratories, 2201 W, 21st Street, Lawrence, KS 66044, USA

Abstract

Abstract The intestinal absorption of α-methyldopa from perfused segments of rat intestine was determined. Jejunal and ileal segments were studied at pH 4.5, 6.0 and 7.4 at an α-methyldopa concentration of 0.01 mM, and at pH 6.0 at concentrations of 0.01, 0.10 and 10 mM. Intestinal absorption was found to depend on both concentration and pH but not on segment. A weak positive correlation (r = 0.5) was observed between net water absorption and α-methyldopa absorption, similar to that observed for amino acids. The low intestinal wall permeability of α-methyldopa under normal intestinal pH conditions (pH 7.4) is consistent with the incomplete oral bioavailability of this drug.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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