Properties of amiodarone monolayer spread at the air–water interface-Reference-Cited by-同舟云学术

Properties of amiodarone monolayer spread at the air–water interface

Published:1986-08 Issue:8 Volume:38 Page:561-566
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Ferreira Jeanine¹,Brasseur Robert¹,Chatelain Pierre²,Ruysschaert Jean-Marie¹

Affiliation:

1. Laboratoires de Chimie Physique des Macromolécules aux Interfaces CP 206/2, Université Libre de Bruxelles, B-1050 Brussels and

2. Sanofi Research, Labaz-Sanofi Research Centre, B-1120 Brussels, Belgium

Abstract

Abstract Surface pressure measurements demonstrate that, over a wide range of pH, amiodarone forms a stable monolayer at the air–water interface. The area found to be occupied by an amiodarone molecule was compared with a theoretical prediction based on a conformational analysis, making it possible to assemble amphiphilic molecules. The intrinsic ionization constant of amiodarone in an aqueous environment pKi = 8.7 ± 0.5 was evaluated from surface potential measurements.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/38/8/561/37612237/j.2042-7158.1986.tb03081.x.pdf

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