The affinity of some selective muscarinic receptor antagonists for the muscarinic receptor mediating endothelial-dependent relaxation of the rabbit and rat thoracic aorta-Reference-Cited by-同舟云学术

The affinity of some selective muscarinic receptor antagonists for the muscarinic receptor mediating endothelial-dependent relaxation of the rabbit and rat thoracic aorta

Published:1986-11 Issue:11 Volume:38 Page:843-845
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Choo L K¹,Malta E¹,Mitchelson F¹

Affiliation:

1. School of Pharmacology, Victorian College of Pharmacy, 381 Royal Parade, Parkville 3052, Victoria, Australia

Abstract

Abstract The pKB values determined for pirenzepine, 4-DAMP, secoverine and gallamine against acetylcholine-mediated relaxant effects in rabbit aorta indicate that this muscarinic receptor closely resembles that which mediates contraction of non-vascular smooth muscle. The results of the present study argue against the presence of a novel type of muscarinic receptor mediating endothelium-dependent relaxation.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/38/11/843/37533998/j.2042-7158.1986.tb04507.x.pdf

Reference20 articles.

1. A COMPARISON OF AFFINITY CONSTANTS FOR MUSCARINE-SENSITIVE ACETYLCHOLINE RECEPTORS IN GUINEA-PIG ATRIAL PACEMAKER CELLS AT 29°C AND IN ILEUM AT 29°C AND 37°C

2. COMPARISON OF THE AFFINITY OF SECOVERINE FOR SOME MUSCARINIC RECEPTORS

3. THE INHIBITORY EFFECT OF GALLAMINE ON MUSCARINIC RECEPTORS

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