Calculated and actual changes in β-adrenoceptor number associated with increases in rat and guinea-pig cardiac sensitivity-Reference-Cited by-同舟云学术

Calculated and actual changes in β-adrenoceptor number associated with increases in rat and guinea-pig cardiac sensitivity

Published:1986-12 Issue:12 Volume:38 Page:902-906
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Chess-Williams Russell G¹,Broadley Kenneth J¹,Sheridan Desmond J²

Affiliation:

1. Cardiovascular Research Laboratory, Department of Pharmacology, Welsh School of Pharmacy, University of Wales Institute of Science and Technology, PO Box 13

2. Department of Cardiology, University of Wales College of Medicine, Cardiff CF4 4XN, UK

Abstract

Abstract Chronic catecholamine depletion induced by reserpine pretreatment of rats, or 6-hydroxydopamine pretreatment of guinea-pigs, resulted in an enhanced sensitivity of isolated papillary muscles to isoprenaline. This hypersensitivity was accompanied by l.41-(rats) and 1.52-fold (guinea-pigs) increases in the number of [3H]dihydroalprenolol binding sites, without changes in binding affinity. An equation was derived for calculation of increases in receptor number. Application of this showed that substantially greater increases in receptor number were required (2.32- to 4.04-fold) to account for the degree of supersensitivity observed.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/38/12/902/37533948/j.2042-7158.1986.tb03380.x.pdf

Reference16 articles.

1. SELECTIVE RESERPINE-INDUCED SUPERSENSITIVITY OF THE POSITIVE INOTROPIC AND CHRONOTROPIC RESPONSES TO ISOPRENALINE AND SALBUTAMOL IN GUINEA-PIG ISOLATED ATRIA

2. Studies on β-adrenoceptors mediating changes in mechanical events and adenosine 3′,5′-monophosphate levels. Rat atria

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