Affiliation:
1. Istituto di Ricerche Farmacologiche ‘Mario Negri’ via Eritrea 62, 20157 Milan, Italy
Abstract
Abstract
The influence of denzimol. a new imidazole derivative with anticonvulsant properties, on the disposition of diazepam (1 mg kg−1) was investigated in the rat. Denzimol pretreatment significantly increased plasma and brain concentrations of the benzodiazepine, consistent with reduced total clearance. The results suggest that the increase of diazepam brain concentrations by denzimol may produce enhancement of diazepam activity in the rat.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献