Buspirone decreases the activity of 5-hydroxytryptamine-containing dorsal raphe neurons in-vitro-Reference-Cited by-同舟云学术

Buspirone decreases the activity of 5-hydroxytryptamine-containing dorsal raphe neurons in-vitro

Published:1986-05 Issue:5 Volume:38 Page:380-382
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Trulson Michael E¹,Arasteh Kamyar¹

Affiliation:

1. Department of Anatomy, College of Medicine, Texas A & M University, College Station, Texas 77843, USA

Abstract

Abstract Buspirone, a non-benzodiazepine anxiolytic agent, produced a dose-dependent decrease in the activity of 5-HT-containing dorsal raphe neurons recorded from mouse brain slices. The response was not changed in a low calcium/high magnesium incubation medium, indicating that the observed effects were the result of a direct action of buspirone on raphe neurons. These data are discussed within the context of the anxiolytic effects of buspirone.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/38/5/380/37552702/j.2042-7158.1986.tb04591.x.pdf

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