Molecular interactions of caffeine with o-, m- and p-iodobenzoic acids and o-, m- and p-fluorobenzoic acids

Author:

DONBROW M1,BEN-SHALOM H1

Affiliation:

1. School of Pharmacy, Hebrew University, P.O.B. 517, Jerusalem, Israel

Abstract

Abstract The solubilities of o-, m- and p-iodo- and fluorobenzoic acids in aqueous solutions of caffeine increase linearly with caffeine concentration due to complex-formation. Insoluble complexes are formed by the o- and m-acids and soluble ones by the p-acids. Approximate 1:1 stability constants have been evaluated from the phase diagrams and their values are considered in relation to possible mechanisms of complex-formation.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Thermodynamic properties of organic iodine compounds;Geochimica et Cosmochimica Acta;2011-11

2. References;Handbook of Aqueous Solubility Data, Second Edition;2010-04-26

3. References;Handbook of Aqueous Solubility Data, Second Edition;2010-04-26

4. Die kernresonanzspektrographische Untersuchung der Assoziation von Coffein mit Natriumbenzoat und einigen anderen Verbindungen;Archiv der Pharmazie;1969

5. Pharmaceutical Sciences—1967;Journal of Pharmaceutical Sciences;1968-07

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