Micelles as simple models of drug receptors

Abstract

Abstract Some interactions of optically active N-alkyl-NN-dimethylalanine hydrobromide (alkyl betaine) micelles, representing model flexible drug receptors, with simple “drug” molecules, represented by a number of optically active amino-acids, choline derivatives and a dipeptide have been examined. Comparisons of these “drug-receptor” interactions have been made using a refractive index technique and an explanation of the difference in the degree of adsorption of different “drug” molecules at identical micelle surfaces is advanced.