Affiliation:
1. Department of Pharmacology, University of Sydney, Australia
Abstract
Abstract
Tissue extracts of the urinary bladder of the rat, cat and guinea-pig contain an acetylcholine-like substance which is considered to be stored predominantly in post-ganglionic nerve fibres. An acetylcholine-like substance was liberated into the fluid bathing the isolated bladder of the guinea-pig and its output was increased 200-fold after transmural stimulation. The acetylcholine-like substance, both from bladder extracts (rat, cat and guinea-pig) and perfusates (rat), was found at the same Rf value as acetylcholine chloride when separated by paper chromatography in three solvent systems. It is concluded that the substance was acetylcholine.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
39 articles.
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