An in vitro model for soluble drug absorption

Abstract

Abstract A physico-chemical model is proposed to simulate the transfer of a drug through a lipoidal membrane. The drug is transferred from a buffer of a pH found in the gut, through an immiscible organic liquid acting as the membrane, to a buffer of the plasma pH (7.4). The transfer of salicylic acid and amidopyrine obeys the theoretical equations. The apparatus used has the advantage that there is little or no danger of emulsion formation because of the lack of disturbance at the interface and the ease of removing samples for analysis.