Effect of Topical Preparation of Mycophenolic Acid on Experimental Allergic Contact Dermatitis of Guinea-pigs Induced by Dinitrofluorobenzene-Reference-Cited by-同舟云学术

Effect of Topical Preparation of Mycophenolic Acid on Experimental Allergic Contact Dermatitis of Guinea-pigs Induced by Dinitrofluorobenzene

Published:1994-08 Issue:8 Volume:46 Page:643-646
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Shoji Yoko¹,Fukumura Tadashi¹,Kudo Masataka¹,Yanagawa Akira¹,Shimada Jingoro¹,Mizushima Yutaka¹

Affiliation:

1. Institute of Medical Science, Department of Clinical Pharmacology, St Marianna University School of Medicine, 2–16–1 Sugao, Miyamae-ku, Kawasaki 216, Japan

Abstract

Abstract The effects of a topical preparation of mycophenolic acid on the experimental allergic contact dermatitis induced by dinitrofluorobenzene was investigated. Visual assessment of skin reactions showed significant efficacy of a topical preparation of mycophenolic acid. This efficacy appeared from the early stage and endured up to 3 days. Morphological changes in the epidermis and dermis layers of animals treated with a mycophenolic acid cream were moderate compared with that in animals treated with vehicle only. In particular, hyperkeratosis was strongly suppressed. Since suppression of inflammatory cell infiltration was also observed, this efficacy might reach to the epidermis and dermis layer.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/46/8/643/36993723/j.2042-7158.1994.tb03874.x.pdf

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