Evaluation of free radical production in an ischaemia-reperfusion model in the rabbit using a tourniquet-Reference-Cited by-同舟云学术

Evaluation of free radical production in an ischaemia-reperfusion model in the rabbit using a tourniquet

Published:1994-06 Issue:6 Volume:46 Page:519-520
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Chopineau J¹,Sommier M F¹,Sautou V¹

Affiliation:

1. Laboratoire de Pharmacie Clinique et Biotechnique, Faculté de Pharmacie, Place Henri Dunant-BP 38, 63003 Clermont-Ferrand Cedex 1, France

Abstract

Abstract Use of a tourniquet on a limb to stem blood flow is frequent in surgery. However, this results in an ischaemia-reperfusion effect that causes damage through the production of free radicals. The aim of this work was to evaluate this production of free radicals in an ischaemia-reperfusion model in the rabbit after placement of a tourniquet. Plasma lipoperoxides were measured by high-performance liquid chromatography using the malondialdehyde assay method. We found significant (P < 0·01) production of free radicals 1 min after release of the tourniquet compared with controls; no variation in levels of free radicals was observed during the ischaemia phase.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/46/6/519/36993569/j.2042-7158.1994.tb03842.x.pdf

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