Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the dissociation of the drug

Author:

Sakane Toshiyasu1,Akizuki Motohiro1,Yamashita Shinji1,Sezaki Hitoshi1,Nadai Tanekazu1

Affiliation:

1. Faculty of Pharmaceutical Sciences, Setsunan University, Japan

Abstract

Abstract We aimed to clarify the relationship between drug dissociation (sulphisomidine) and its direct transport from the nasal cavity to the cerebrospinal fluid (CSF). Rat nasal cavities were perfused in a single pass system with buffers (pH 5·5, 6·5, 7·4, 8·7 and 9·4). Plasma and CSF were collected and the concentration of sulphisomidine was measured. Nasal clearance increased with the increase in the un-ionized fraction of the drug. The ratio of the drug concentration in CSF to that in the nasal perfusion fluid (the index of the degree of the drug transport from the nasal cavity to CSF), was changed in accordance with the un-ionized fraction of drug. These results show that both the nasal absorption and the drug transport conform to the pH partition theory.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference17 articles.

1. Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit;Bradbury;Am. J. Physiol.,1981

2. Experimental investigations on the penetration of Au from nasal mucous membrane into cerebrospinal fluid;Czerniawska;Acta Otolaryngol.,1970

3. Ueber den Zusammenhang der nasalen Lymphbahnen mit dem Subarachnoidealraum;Flatau;Deutsch. Med. Wochenschr.,1890

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