Human Calcitonin Delivery in Rats by Iontophoresis-Reference-Cited by-同舟云学术

Human Calcitonin Delivery in Rats by Iontophoresis

Published:1994-09 Issue:9 Volume:46 Page:725-730
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Thysman Sophie¹,Hanchard Cecile¹,Préat Veronique¹

Affiliation:

1. Université Catholique de Louvain, Ecole de Pharmacie, Unité de Pharmacie Galénique, Av. E. Mounier 73/20, 1200 Brussels, Belgium

Abstract

Abstract In-vitro iontophoresis (0·33 mA cm−2) of calcitonin (50 μg mL−1, pH 4) was performed with the hairless rat skin model. Direct current was as potent as pulse current (2·5 kHz on/off 1/1) iontophoresis in promoting transdermal permeation of calcitonin. Increase in duration of current application from 20 min to 1 h did not increase calcitonin flux. Results suggest that calcitonin can be blocked in the skin pores through which it travels or can accumulate in the skin and be progressively released from the depot. Invivo experiments showed that transdermal iontophoretic administration of calcitonin induced a hypocalcaemic effect in rats.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/46/9/725/36993777/j.2042-7158.1994.tb03891.x.pdf

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