Affiliation:
1. Laboratoire de Pharmacologic, Hôpital Maison Blanche, 45 rue Cognacq-Jay, Reims
2. Laboratoire de Pharmacologic, CHRU, Caen, France
Abstract
Abstract
The pharmacokinetics of zolpidem were studied after single dose, administered for either 7 or 28 days to rats. Thirty minutes after the last dose, animals were killed and the brain removed. The highest concentrations in plasma, which were observed at the first sampling time (0·5 h) were 2341±540 (day 0), 1956 ± 325 (day 7) and 2908 ± 1369 ng mL−1 (day 28). Corresponding AUC values of 1742 ± 488, 1583 ± 422 and 2683 ± 1249 ng mL−1 h were found. MRT increased significantly from 0·46 ± 0·06 h on day 0 to 0·67 ± 0·02 h on day 28. The cerebral levels showed no significant change during the chronic administration (766 ± 285, 685 ± 171 and 887 ± 264 ng g−1, respectively). No modification of the principal kinetic parameters was detected up to the 28th day of treatment.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference22 articles.
1. Pharmacological profile of zolpidem at benzodiazepine receptors and electrocorticogram in rats;Arbilla;Naunyn Schmiedebergs Arch. Pharmacol.,1985
2. In vivo interaction of zolpidem with central benzodiazepine (BZD) binding sites (as labeled by [3H] Ro15–1788) in the mouse brain. Preferential affinity of zolpidem for the ω1 (BZD1) subtype;Benavides;J. Pharmacol. Exp. Ther.,1988
3. Comparative autoradiographic distribution of ω (benzodiazepine) modulatory site subtypes with high, intermediate and low affinity for zolpidem and alpidem;Benavides;Brain Res.,1993
4. Clinical pharmacokinetics of zolpidem in various physiological and pathological conditions;Bianchetti,1988
5. Diazepam receptor: specific binding of 3H-diazepam and 3H-flunitrazepam to rat brain subfractions;Bosmann;FEBS Lett.,1978
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献