Effect of Terfenadine on Substance P and Vasoactive Intestinal Polypeptide Concentrations in Nasal Secretions from Patients with Nasal Allergy-Reference-Cited by-同舟云学术

Effect of Terfenadine on Substance P and Vasoactive Intestinal Polypeptide Concentrations in Nasal Secretions from Patients with Nasal Allergy

Published:1994-01 Issue:1 Volume:46 Page:41-45
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Takeyama Masaharu¹,Mori Kazuo¹,Morikawa Norifumi¹,Asakura Shunji¹,Chaen Tokuo²,Watanabe Noritake²,Mogi Goro²

Affiliation:

1. Department of Clinical Pharmacy, Oita Medical University, Hasama-machi, Oita-gun, Oita 879–55, Japan

2. Department of Otolaryngology, Oita Medical University, Hasama-machi, Oita-gun, Oita 879–55, Japan

Abstract

Abstract Before terfenadine treatment, the mean substance P and vasoactive intestinal polypeptide (VIP) concentrations in nasal secretions from nasal allergy patients tended to be higher than the values of healthy subjects. During terfenadine treatment, the mean substance P concentrations in nasal secretions from patients allergic to house dust or pollen were significantly decreased to 62 and 39% of the initial values, respectively. The mean VIP concentrations in nasal secretions from the house dust allergy patients and the pollen allergy patients were significantly decreased to 52 and 18% of the initial values, respectively. Plasma substance P and VIP concentrations were not affected by nasal allergic symptom and terfenadine treatment.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/46/1/41/36992612/j.2042-7158.1994.tb03717.x.pdf

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