Affiliation:
1. Department of Pharmaceutical Chemistry, University of Pavia, 12 viale Taramelli, 27100 Pavia, Italy
Abstract
Abstract
The preparation of hydrophilic matrix tablets able to release naftazone, a water-insoluble drug, into an aqueous medium at a constant rate (zero-order dissolution) is described. Enhancement of dissolution rate of the drug was achieved using cross-linked carmellose sodium, β-cyclodextrin or hydroxypropyl-β-cyclodextrin. Hypromellose was used as a water-gelling polymer. Tablets could be prepared that released naftazone at a constant rate over 16 h.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
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