Affiliation:
1. Department of Pharmacy, Chelsea College of Science and Technology (University of London), Manresa Road, S.W.3
Abstract
Abstract
Infrared spectroscopy and differential scanning calorimetry data are given for the characterisation of three anhydrous and two hydrated crystal modifications of cortisone acetate. All forms revert to the same form on heating to 200°. The amount of hydration estimated from thermal analysis varies from half to one molecule of water per molecule of cortisone acetate. Methods for the preparation of the five forms are described emphasising the importance of solvent composition, particularly its water content. Interconversion of these forms under various conditions such as grinding, contact with water and heat treatment is discussed.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
22 articles.
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