Anticurare activity of tacrine (THA) in vitro

Abstract

Abstract Tacrine (tha) has been found to be a relatively weak anticurare agent having a significant anticurare activity on the rat isolated phrenic nerve diaphragm preparation in concentrations above 10−7 m. It is about 20 times less potent than neostigmine. Between 10−5 m and 10−4 m, anticurare activity of tha ceases to be reproducible, and in concentrations above 10−4 m the compound exerts a depressant action directly on the muscle. The qualitative and quantitative differences between the anticurare activities of tha and neostigmine are discussed.