The passage of drugs across the rat intestine in vitro

Author:

MISRA ANAND L1,HUNGER ALFRED1,KEBERLE HEINRICH1

Affiliation:

1. CIBA Ltd., Basle, Switzerland

Abstract

Abstract The in vitro methods of Smyth & Taylor (1957) and everted sac technique of Crane & Wilson (1958) have been evaluated for studying the passage of ferrioxamine-B hydrochloride and its derivatives, glutethimide, thalidomide, a polypeptide, salicylic acid, aniline and phenol red from the mucosal to serosal side of the rat intestinal barrier in vitro. The ferrioxamines were not significantly absorbed, glutethimide was more rapidly absorbed than thalidomide, the polypeptide was broken down rapidly and appeared as amino-acids in the serosal fluid, salicylic acid and aniline were found in the serosal fluid but phenol red was little absorbed. Although allowance must be made for differences in the transit pathways of in vivo and in vitro systems because of the non-functional nature of the capillary network in in vitro studies, our results suggest that these methods can supply useful information on the permeability characteristics of newly developed drugs through the intestinal barrier.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Evaluation of a Chronically Isolated Internal Loop in the Rat for the Study of Drug Absorption Kinetics;Journal of Pharmaceutical Sciences;1987-06

2. Acute Iron Poisoning;American Journal of Diseases of Children;1980-09-01

3. Pharmacology and therapeutic applications of agents used in heavy metal poisoning;Pharmacology & Therapeutics. Part A: Chemotherapy, Toxicology and Metabolic Inhibitors;1976-01

4. Drug Transport VI: Functional Integrity of the Rat Everted Small Intestine with Respect to Passive Transfer;Journal of Pharmaceutical Sciences;1972

5. Drug Absorption I: An In Situ Rat Gut Technique Yielding Realistic Absorption Rates;Journal of Pharmaceutical Sciences;1969-10

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