Effect of solubilisation on the antibacterial activity of hexachlorophane

Author:

Anderson R A1,Morgan K J1

Affiliation:

1. Pharmacy Department, University of Sydney, Australia

Abstract

Abstract The solubilisation of hexachlorophane by various non-ionic agents has been studied at pH 2·5 and 8·0. The interaction of the phenol with these agents in unsaturated systems at pH 8·0 has been determined by a dialysis technique using rubber latex membranes. The bactericidal activity is shown to depend on the concentration of unbound hexachlorophane, but this is not simply related to the degree of saturation of the total system. The results of agar-plate diffusion tests cannot be correlated with either the concentration of unbound hexachlorophane or the total concentration.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Correlation of antimicrobial effects of phenoxyethanol with its free concentration in the water phase of o/w-emulsion gels;European Journal of Pharmaceutics and Biopharmaceutics;2018-10

2. A reaction limited in vivo dissolution model for the study of drug absorption: Towards a new paradigm for the biopharmaceutic classification of drugs;European Journal of Pharmaceutical Sciences;2018-05

3. References;Handbook of Aqueous Solubility Data, Second Edition;2010-04-26

4. References;Handbook of Aqueous Solubility Data, Second Edition;2010-04-26

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